The prevalence of diabetes mellitus has reached epidemic proportions and has affected 6.4% of adults worldwide in 2010 ( 2). Effective control of hyperglycemia in diabetic patients is critical for reducing the risk of micro- and macro-vascular diseases ( 1). Type 2 diabetes accounts for >90% of diabetes and is resulting in impaired function in carbohydrate, lipid and protein metabolism. So it may have a role in alleviating the risk of some chronic complications of diabetes.Дiabetes mellitus can be defined as a group of metabolic diseases characterized by chronic hyperglycemia resulting from impaired insulin action/secretion and is classified into two major categories, type 1 and type 2. It seems that oral administration of ginger powder supplement can improves fasting blood sugar, hemoglobin A1c, apolipoprotein B, apolipoprotein A-I, apolipoprotein B/apolipoprotein A-I and malondialdehyde in type 2 diabetic patients.

Ginger supplementation significantly reduced the levels of fasting blood sugar, hemoglobin A1c, apolipoprotein B, apolipoprotein B/apolipoprotein A-I and malondialdehyde in ginger group in comparison to baseline, as well as control group, while it increased the level of apolipoprotein A-I (p<0.05). The serum concentrations of fasting blood sugar, Hemoglobin A1c, apolipoprotein B, apolipoprotein A-I and malondialdehyde were analyzed before and after the intervention. In a randomized, double-blind, placebo-controlled, clinical trial, a total of 41 type 2 diabetic patients randomly were assigned to ginger or placebo groups (22 in ginger group and 19 in control group), received 2 g/day of ginger powder supplement or lactose as placebo for 12 weeks. The present study was conducted to investigate the effects of ginger on fasting blood sugar, Hemoglobin A1c, apolipoprotein B, apolipoprotein A-I, and malondialdehyde in type 2 diabetic patients. Anti-diabetic, hypolipidemic and anti-oxidative properties of ginger have been noticed in several researches.

Diabetes mellitus is the most common endocrine disorder, causes many complications such as micro- and macro-vascular diseases.

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